"Splice" is a 2010 science fiction horror film directed by Vincenzo Natali. The movie follows the story of two genetic engineers, played by Adrien Brody and Sarah Polley, who splice together DNA from different animals to create a hybrid creature for medical research.
As their experiment progresses, they create a humanoid creature named Dren, who rapidly grows and exhibits both animal and human characteristics. Despite their initial excitement, the scientists soon realize that Dren is much more than they bargained for as she begins to develop her own intelligence, emotions, and dangerous tendencies.
As Dren's behavior becomes increasingly unpredictable and violent, the scientists must confront the ethical and moral implications of their creation while also trying to control her. However, their efforts are complicated by personal and professional conflicts, leading to a series of shocking and horrifying events.
"Splice" is praised for its thought-provoking premise, chilling atmosphere, and impressive special effects. Adrien Brody and Sarah Polley deliver strong performances as the conflicted scientists, while Delphine Chanéac shines as the enigmatic and unsettling Dren.
The film explores themes of scientific ethics, parental responsibility, and the consequences of playing god, offering a disturbing and thought-provoking take on the classic Frankenstein story. While "Splice" received mixed reviews from critics, it has gained a cult following among fans of science fiction and horror for its unique premise and unsettling portrayal of genetic engineering gone wrong.